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Spinal Roundtable Discuss Trigosamine, Glucosamine, SAMe...oh my in the General Discussion forums; Someone recently asked me about trigosamine, which got me thinking about past conversations on similar products for joint health. I ...

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Old 06-23-2006, 06:28 AM
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Someone recently asked me about trigosamine, which got me thinking about past conversations on similar products for joint health. I could not find any reputable web sites on this product. If anyone has any insights, references or experience with this, please let us know.

In the meantime, here are some recent topics that may be helpful to some of you considering similar products for joint health.


Glucosamine/chondroitin allergy?
http://adrsupport.org/eve/forums/a/tpc/f/4601036081/m/4...501008081#4501008081

SAMe for joint health and pain
http://adrsupport.org/eve/forums/a/tpc/f/4601036081/m/6...801017081#7801017081

Glucosamine recommendation anyone?
http://adrsupport.org/eve/forums/a/tpc/f/7701036081/m/7...041076081#7041076081

Efficacy of Glucosamine
http://adrsupport.org/eve/forums/a/tpc/f/4601036081/m/8...441058081#8441058081

Alternative bone density builders
http://adrsupport.org/eve/forums/a/tpc/f/4601036081/m/5...431058281#4431058281
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Old 06-23-2006, 11:38 AM
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This is interesting folks, we had a girl called Jo, who had a disc problem and she took this and it seemed to cure her problem altogether. She was a photographer who had previously been a physiotherapist -- -- -- as far as I know she's fine.

This just shows that it is the correct thing to try the least invasive things first. ADR is the end of a long painful road for most of us
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Old 06-23-2006, 12:20 PM
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I have had positive results with some of these products. One of the keys is to purchase from a reputable seller and select products that are high quality. I believe I listed some websites or links on previous threads regarding holistic treatments.
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Old 08-24-2006, 06:32 PM
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Conflicting data on glucosamine, chondroitin sulfate concerns public, physicians

Expert suggests combined treatment works, recommends three-month trial for patients.
By Tina DiMarcantonio
ORTHOPEDICS TODAY 2006; 26:24

August 2006

Patients and physicians alike are struggling to sift through the often-conflicting information on glucosamine and chondroitin sulfate use for relieving osteoarthritis pain.

The most significant contribution to this confusion: A National Institutes of Health (NIH)-funded study – known as the Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT) – which was presented at the 2005 American College of Rheumatology (ACR) meeting.

In the study abstract, researchers concluded that glucosamine and chondroitin sulfate effectively treat moderate-to-severe osteoarthritis knee pain, according to David S. Hungerford, MD, orthopedic surgeon at The Johns Hopkins University in Baltimore.

David S. Hungerford, MD [photo]
David S. Hungerford


“From the podium, however … [the study’s principal author, Daniel O. Clegg, MD] concluded, ‘Glucosamine and chondroitin sulfate are no better than placebo,’” Hungerford told colleagues at the 7th Annual Current Concepts in Joint Replacement Spring 2006 Meeting.

The contradictions did not stop there. “This has led to a lot of controversy in the lay public, with articles in the New York Times saying that the GAIT study shows no significant effect of nutraceuticals, and then Clegg appearing in a post-ACR meeting saying that there was some significance. So, it’s confusing,” Hungerford said.

Hungerford said that the GAIT study contradictions might be related to a variation in evaluation methods, including the WOMAC Osteoarthritis Index and the Outcome Measures in Rheumatology (OMERACT) score.

The GAIT study, a five-arm multicenter study beginning in 1999, enrolled roughly 1,500 patients. Researchers randomized patients to receive glucosamine alone, chondroitin sulfate alone, combined glucosamine and chondroitin sulfate, Celebrex, or placebo.

Among patients with a WOMAC pain score of 125 mm to 300 mm, those taking Celebrex reported the only statistically significant improvement (P=.04).

“But with a WOMAC pain score [of 301 mm to 400 mm], the combination of glucosamine and chondroitin sulfate (79.2%) is statistically significant (P=.002), and Celebrex, interestingly enough, is not statistically significant in this group,” Hungerford said.
No response in mild pain group

Although the researchers found that glucosamine and chondroitin sulfate effectively treated moderate-to-severe osteoarthritis, they found no response in patients with mild pain because of a “floor effect” that limited the ability to detect a response, he said.

chart
In patients with a low WOMAC pain stratum, celecoxib shows significant improvement, while glucosamine and chondroitin sulfate do not. But the roles are reversed on the higher pain scale.

Source: Hungerford DS

Overall, the researchers said there was a significant improvement with Celebrex and not for the combined glucosamine and chondroitin sulfate. However, the researchers enrolled significantly fewer patients in the moderate-to-severe group compared to the mild group, Hungerford said.

He also found that the WOMAC score might not be sensitive enough to detect all changes and requires a 20% improvement for a positive response.

“If you look at the OMERACT … [there] was [a] statistically significant difference for both Celebrex and glucosamine and chondroitin [sulfate] for the group as a whole,” Hungerford said.
Three-month trial recommended

Hungerford has recommended the combined therapy in his practice for 10 years and believes that a three-month trial is the best approach. “If a patient responds, then he or she should continue. If the patient doesn’t respond, you don’t continue,” he said.

No study has shown negative side effects with glucosamine and chondroitin sulfate, such as those found with some NSAIDs like Vioxx, he said. Consequently, “[the combination] is a reasonable thing to apply to your patients, and [it’s] basically risk-free.”

For more information:

* Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006;354:795-808.
* Hungerford D. Over-the-counter interventions: What a difference a decade makes. #65. Presented at the 7th Annual Current Concepts in Joint Replacement Spring 2006 Meeting. May 21-24, 2006. Las Vegas.

Courtesy of:
http://www.orthosupersite.com/defaul...view&rid=18004
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  #5  
Old 08-25-2006, 01:42 AM
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Can someone tell me what trigosamine is, Ive never heard of it?
As for glucosamine and chondroitin, Ive been taking them in powdered form for about 3 years, both before and after surgery. I really don't know whether they have much benefit or not but they don't seem to be doing any harm, so why not?
Is Celebrex still available in the States? It's been withdrawn here along with Voixx.
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Old 08-25-2006, 06:43 AM
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From their website:
Trigosamine™ combines three powerful joint compounds; Hyaluronate, Glucosamine and Chondroitin in a new once-daily, dose that is available without a prescription. These three essential building blocks are needed by the body to maintain health joints.

There was a full page ad in our local newspaper a few weeks back about Trigosamine. According to the ad, there is such a huge demand for this product, the company had toll free numbers for some states to help you get some if you wanted it. The ad was really pushing that demand was higher thant he supply for Trigosamine.
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