I'm dumb as a post from an all-nighter but I think that I read if one is on opiates, it can diminish the veracity of the PSA test (but I Googled for it and couldn't find it).
You raise a good/scary issue as a semi-recent CT or MRI showed mild irregular borders of my prostate. I hear the biopsy hurts like you know what.
Better safe than sorry and good luck.
Best...
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Severe, extensive DDD, considered inoperable by Dr. Regan, Lauressen, & some guy at UCLA. Severe foraminal stenosis (guess they can't operate!) and some spinal cord compression that Lauryssen would fix if gets outta hand.
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