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Old 06-20-2012, 10:44 AM
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Harrison Harrison is offline
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Material reactivity throws another wrinkle into the human process, perhaps literally. When a metal interacts (reacts) with the human body, the immune system will cloak the device (doesn’t matter if it’s plastic, metal) with all kinds of biochemicals ranging from proteins to T Cells.

This is really complicated stuff; bear in mind that the immune processes will vary in accordance to the implant type and procedure. E.g., dental implants are more complicated: teeth are a bridge between the bloodstream and a complex oral system of saliva 600+ microbes, some of which are pathogenic.

Furthermore, the material reactivity likely plays a critical process in the area of biofilm development, but this area of development is still nascent, so research is sparse. Some related links below.

Histological and ultrastructural reaction to different materials for orthopaedic application.
Histological and ultras... [Int J Immunopathol Pharmacol. 2011 Jan-Mar] - PubMed - NCBI
(requested this article from the authors)

Metal Corrosion in the Human Body:The Ultimate Bio-Corrosion Scenario

Electrochemical Corrosion of Metal Implants
Electrochemical Corrosion of Metal Implants

An in vitro assessment of wear particulate generated from NUBAC: a PEEK-on-PEEK articulating nucleus replacement device: methodology and results from a series of wear tests using different motion profiles, test frequencies, and environmental conditions.
An in vitro assessment of wear particu... [Spine (Phila Pa 1976). 2011] - PubMed - NCBI

Oral Mucosa Tissue Response to Titanium Cover Screws.
Oral Mucosa Tissue Response to Titanium Cover ... [J Periodontol. 2011] - PubMed - NCBI

A good cheat sheet (overview) of typical infection processes:

Please note: this overview contrasts slightly with newer paradigms of infection; particularly biofilm infections. E.g., the last step in the host-infection process states that "The host recovers, remains infected, or succumbs to infection." In actuality, all three conditions can occur simultaneously. Hence, we see the notion of sub-clinical chronic diseases that affect millions.
"Harrison" - info (at)
Fell on my ***winter 2003, Canceled fusion April 6 2004
Reborn June 25th, 2004, L5-S1 ADR Charite in Boston
Founder & moderator of ADRSupport - 2004
Founder Arthroplasty Patient Foundation a 501(c)(3) - 2006
Creator & producer, Why Am I Still Sick? - 2012
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