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Old 03-25-2017, 08:03 PM
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Harrison Harrison is offline
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Default Microbial infections in DDD -- more common that you know

Antibiotics act against back pain - Danish scientist receives German prize

Approximately half of the patients with chronic lower back pain show MR edema in the bone marrow, so-called 'modic changes'. In the first investigations Albert was able to detect bacteria in more than 50% of the patients in the tissue taken after a herniated disc. To a large extent, the tissue was infected with P. acnes. This bacterium, which belongs to the natural oral flora, enters the blood, for example, through small injuries that occur during the brushing process. By newly formed capillaries on the exudated tissue of the disc, the bacteria ultimately reach the inside of the disc, and remain there after a healing of the intervertebral disc disease and cause inflammation, bone edema, and pain.

Thus the idea arose in a pilot study to test whether antibiotics against the bacterial attack and thus also against the back pain of the patients can work. Already this first study showed significant results in the improvement of both the pain symptoms as well as the functional complaints of the patients.

Further randomized, placebo-controlled studies confirm the results. Patients received 1,000 mg amoxicillin 3 times a day over a period of 100 days. First effects were observed after 6 to 8 weeks and continued over a follow-up time of one year, in another study even over two years.

Antibiotics in "modic changes" with bacterial probes

When asked whether all patients with low back pain should be treated with antibiotics, Albert said, "No, but those with modic changes, where bacteria play a role, benefit enormously . "A revolutionary approach to pain medicine that could not only alleviate the suffering of millions of patients, but also save enormous costs due to disability and early retirement. These research efforts have now been awarded the DEUTSCHE SCHMERZPREIS.

"With her breakthrough, Hanne Albert has sustained a change in pain medication and established a new basis for the discussion of chronic back pain," said Dr. Gerhard Müller-Schwefe, President of the German Society of Pain Medicine, in his laudation.

The DEUCHCHE SCHMERZPREIS - Deutscher Förderpreis für Schmerzforschung und Schmerzmedizin - is awarded annually to persons who have earned themselves by scientific work on the diagnosis and therapy of acute and chronic painful conditions, or which, through their work or their public activities, make a decisive contribution to the understanding of the problem of pain and of it Affected patients.
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Fell on my ***winter 2003, Canceled fusion April 6 2004
Reborn June 25th, 2004, L5-S1 ADR Charite in Boston
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