I don't know anything about how it may effect ADR, but I do know that the mother of a close friend of mine swears by that exact combo of Glucosamine and Chondroitin as well as some other vitamin but I'm not sure if it was MSM or not. When I was initially told I had mild arthritis in my lumbar spine and noticed the prescription anti-inflammatory wasn't helping, I turned to the over-the-counter Glucosamine/Chondroitin mixture. At the time I had pretty high hopes of it helping over time. I took it as regularly as possible (would forget a dose or so on weekends sometimes) for about 6 months. Of course, now I know why it and prescriptions weren't working... had a completely different problem going on back there!
I'm not sure how long it takes for those to kick in, but I certainly hope they help you out. in the long run.
