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  #1  
Old 09-09-2007, 05:40 PM
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Should I be Concerned with Wear Debris?

Metal on Metal Joints (Medtronic focused, cancer cases)
http://adrsupport.org/eve/forums/a/tpc/f/7501036081/m/4...251037812#4251037812

Technical Article on High Grade Medical Plastic
http://adrsupport.org/eve/forums/a/tpc/f/7501036081/m/9...771086081#4771086081

Publication: In Vitro Wear Assessment of the Charité Artificial Disc
http://adrsupport.org/eve/forums/a/tpc/f/7501036081/m/1...291017002#1291017002

Publication: Charite vs. Prodisc -- Facet Loading / Core Stresses
http://adrsupport.org/eve/forums?m=5...c&f=7501036081

Metal on Metal Joints
http://adrsupport.org/eve/forums/a/tpc/f/7501036081/m/4...151041022#6151041022

Metal on Metal Joints (Different topic)
http://adrsupport.org/eve/forums/a/tpc/f/7501036081/m/4...251037812#4251037812

The Future of Spinal Arthroplasty: A Biomaterial Perspective
http://adrsupport.org/eve/forums/a/tpc/f/7501036081/m/1...711078081#1711078081

10 million cycles, 20 millions cycles, 85 million?
http://adrsupport.org/eve/forums/a/tpc/f/7501036081/m/1...181071742#2181071742

Publication: Cervical Disc Wear Analysis
http://adrsupport.org/eve/forums/a/tpc/f/7501036081/m/2...721042491#2721042491

Allergies to disc implants? (Focused on wear debris)
http://adrsupport.org/eve/forums/a/tpc/f/7501036081/m/7...081004502#6081004502

Publication: Release of Cr/Co Ions Into the Serum -- Maverick ADR
http://adrsupport.org/eve/forums/a/tpc/f/7501036081/m/3...991048032#3991048032

How long will the Charite' disc last?
http://adrsupport.org/eve/forums/a/tpc/f/7011036081/m/6...251000181#6251000181
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Fell on my ***winter 2003, Canceled fusion April 6 2004
Reborn June 25th, 2004, L5-S1 ADR Charite in Boston
Founder & moderator of ADRSupport - 2004
Founder Arthroplasty Patient Foundation a 501(c)(3) - 2006
Creator & producer, Why Am I Still Sick? - 2012
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Old 06-20-2012, 10:44 AM
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Material reactivity throws another wrinkle into the human process, perhaps literally. When a metal interacts (reacts) with the human body, the immune system will cloak the device (doesn’t matter if it’s plastic, metal) with all kinds of biochemicals ranging from proteins to T Cells.

This is really complicated stuff; bear in mind that the immune processes will vary in accordance to the implant type and procedure. E.g., dental implants are more complicated: teeth are a bridge between the bloodstream and a complex oral system of saliva 600+ microbes, some of which are pathogenic.

Furthermore, the material reactivity likely plays a critical process in the area of biofilm development, but this area of development is still nascent, so research is sparse. Some related links below.
_________________________

Histological and ultrastructural reaction to different materials for orthopaedic application.
Histological and ultras... [Int J Immunopathol Pharmacol. 2011 Jan-Mar] - PubMed - NCBI
(requested this article from the authors)

Metal Corrosion in the Human Body:The Ultimate Bio-Corrosion Scenario
http://www.electrochem.org/dl/interf...u08_p31-34.pdf

Electrochemical Corrosion of Metal Implants
Electrochemical Corrosion of Metal Implants

An in vitro assessment of wear particulate generated from NUBAC: a PEEK-on-PEEK articulating nucleus replacement device: methodology and results from a series of wear tests using different motion profiles, test frequencies, and environmental conditions.
An in vitro assessment of wear particu... [Spine (Phila Pa 1976). 2011] - PubMed - NCBI

Oral Mucosa Tissue Response to Titanium Cover Screws.
Oral Mucosa Tissue Response to Titanium Cover ... [J Periodontol. 2011] - PubMed - NCBI

A good cheat sheet (overview) of typical infection processes:
http://web.biosci.utexas.edu/field/mic361a/steps.htm

Please note: this overview contrasts slightly with newer paradigms of infection; particularly biofilm infections. E.g., the last step in the host-infection process states that "The host recovers, remains infected, or succumbs to infection." In actuality, all three conditions can occur simultaneously. Hence, we see the notion of sub-clinical chronic diseases that affect millions.
__________________
"Harrison" - info (at) adrsupport.org
Fell on my ***winter 2003, Canceled fusion April 6 2004
Reborn June 25th, 2004, L5-S1 ADR Charite in Boston
Founder & moderator of ADRSupport - 2004
Founder Arthroplasty Patient Foundation a 501(c)(3) - 2006
Creator & producer, Why Am I Still Sick? - 2012
Donate www.arthropatient.org/about/donate
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